Lipid peroxidation and antioxidant system in inhalation injury

: Thirty-five patients (aged 45 +/- 2.0 years) with isolated inhalation injury were examined on days 1, 3, and 7 after the injury, Serum concentrations of lipid peroxidation (LPO) products (dienic conjugates, malonic dialdehyde, and degree of lipid oxidation) were increased in all terms of investigation. Studies of the antioxidant system (AOS) showed a decrease in endogenous alpha-tocopherol during all terms, while ceruloplasmin content gradually increased. LPO/AOS imbalance was the most expressed on day 7 after the injury, which indicates intensification of LPO processes in the victims. The results pathogenetically validate the use of antioxidants in combined therapy of patients with inhalation injuries. LPO/AOS imbalance should be evaluated in these patients.