Unusual presentations of Haemophilus influenzae infections in immunocompromised patients

In two years we encountered five invasive Haemophilus influenzae infections in immunocompromised hosts. The clinical presentations, age distribution, and serotypes of organisms were atypical of H. influenzae infections in the pediatric population. All four infections in patients with cancer occurred during remission. Broad-spectrum antibiotic therapy for immunocompromised patients should include coverage for H. influenzae .