Case of corneal melting associated with the use of topical nepafenac.

PURPOSE: To report a case of corneal melting associated with the use of the topical nonsteroidal anti-inflammatory agent Nepafenac. METHODS: Case report and literature review. RESULTS: A 62-year-old woman with a complicated ocular history developed corneal melting associated with the use of Nepafenac. On discontinuation of Nepafenac, the melt rapidly resolved. CONCLUSIONS: Topical nonsteroidal anti-inflammatory agents have been associated with corneal ulceration and stromal melts. This is, to our knowledge, the first reported case involving the new agent, Nepafenac.