Derivatives of 2-oxo-1-pyrrolidine, processes for preparing them and their uses.

A compound having the formula I or a pharmaceutically acceptable salt thereof (Formula I) wherein X is -CA1NR5R6 or -CA1R8; A1 and A2 are independently oxygen, sulfur or -NR 9; R1 is hydrogen, C1-20 alkyl, aryl or -CH2-R1a, where R1a is aryl, heterocycle, halogen, hydroxy, amino, nitro or cyano; R3 is hydrogen, halogen, thiol, nitro, nitrooxy, cyano, azido, carboxy, amido, sulfonic acid, sulfonamide, C1-20 alkyl, alkenyl, alkynyl, ester, ether, aryl, heterocycle, alkynyloxy, acyloxy, oxyester, oxyamido, alkylsulfonyloxy, alquilsulfiniloxi, arylsulfonyloxy, arilsulfiniloxi, aryloxy, aralkoxy, heterocyclooxy or thio derivative, acyl derivative, sulfonyl derivative or sulfinyl derivative; R3a is hydrogen, C1-20alkyl, alkenyl, alkynyl or aryl; R5, R6 and R9 are identical or different and each is independently hydrogen, hydroxy, C1-20 alkyl, aryl, heterocycle or oxy derivative; and R8 is hydrogen, hydroxy, thiol, halogen, C1-20 alkyl, aryl, heterocycle or a thio derivative; each alkyl may be optionally substituted independently by 1 to 5 halogen, hydroxy, thiol, amino, nitro, cyano, thiocyanato, acyl, acyloxy, sulfonyl derivative, sulfinyl derivative, alkylamino, carboxy, ester, ether, amido, azido, cycloalkyl , sulfonic acid, sulfonamide, thio derivative, oxyester, oxyamido, heterocycle, vinyl, C1-5 alkoxy, C6-10 aryloxy or C6-10 aryl; each aryl may be optionally substituted independently by 1 to 5 halogen, hydroxy, thiol, amino, nitro, cyano, acyl, acyloxy, sulfonyl, sulfinyl, alkylamino, carboxy, ester, ether, amido, azido, sulfonic acid, sulfonamide, alkylsulfonyl, alkylsulfinyl, alkylthio, oxyester, oxyamido, aryl, alkoxy C.sub.1-6, aryloxy C1-6, C1-6 alkyl, C1-6 haloalkyl.