One-Step Cell-Based Cartilage Repair in the Knee Using Hyaluronic Acid-Based Scaffold Embedded with Mesenchymal Stem Cells Sourced from Bone Marrow Aspirate Concentrate (HA-BMAC)

Articular cartilage injury of the knee is a frequent target of regenerative therapies that are continually being developed to address the extraordinary effect that this condition has on functional capacity and lifestyle. Retaining healthy articular cartilage is necessary for a well-functioning and pain-free knee joint and is of particular priority to those who are physically active. Developments in cell-based cartilage repair have enabled the treatment of high-grade, multifocused cartilage injury of the knee. Ideally, treating this condition is performed as a single-stage procedure to reduce cost and to minimize patient morbidity and socioeconomic impact. The single-stage articular cartilage repair procedure of hyaluronic acid-based scaffold embedded with mesenchymal stem cells sourced from bone marrow aspirate concentrate (HA-BMAC) has demonstrated the capability to restore durable articular cartilage in the knee in cases of solitary or multiple lesions, in cases of multicompartment involvement, and in patients of wide-ranging age.