Инсулинорезистентность у пациентов с артериальной гипертензией в зависимости от риска сердечно-сосудистых осложнений

Objective. To examine the rate of insulin resistance (IR) in groups of different cardiovascular risk in hypertensive patients and to evaluate the effect of IR on risk factors and vascular lesion. Design and methods. The study included 150 patients (82 men and 68 women). Patients were divided into five groups: groups 1–4 included patients with hypertension (HTN) and different level of cardiovascular risk (the SCORE model), 5th group was the control group. Each of the groups was divided into 2 subgroups: patients with and without IR. Results. IR was verified in all groups of cardiovascular risk, but it was predominant in very high-risk patients. IR correlated with body mass index and hypertriglyceridemia. IR rates were equal in middle- and high-risk patients. IR was associated with myocardial remodeling in high-risk group. Conclusions. HOMA-IR index is an important biological marker of the presence of cardiovascular risk factors in hypertensive patients. We believe that an estimate of IR may help to personalize health care and improve the prognosis of hypertensive patients, even in patients without clinical manifestations of IR and impaired glucose metabolism. Further research is needed to study the role of identifying IR in the definition of medical approaches in HTN