Clinical study of ovulation induction in infertility women with polycystic ovary syndrome in the non-menstrual period

Objective To investigate the effects of ovulation induction in infertile women with polycystic ovary syndrome (PCOS) in the non-menstrual period. Methods A total of 529 cycles of infertile women with PCOS were divided into study group (non-menstrual period ovulation induction, n=217) and control group (menstrual period ovulation induction, n=312) according to the peirod of ovulation induction, then they were divided into clomiphene citrate (CC) subgroup (study group, n=151; control group, n=202), and letrozole (LE) subgroup (study group, n=66; control group, n=110). The follicle diameter and endometrial thickness were monitored by the transvaginal ultrasound, and the clinical indexes were observed. Results The stimulation follicle days in study group [CC subgroup (11.9±3.7) d, LE subgroup (12.1±3.2) d] were less than those in control group [CC subgroup (17.5±3.9) d, LE subgroup (19.0±4.7) d] (P=0.011, P=0.018). The dosages of estrodiol in study group [CC subgroup (6.42±2.19) mg, LE subgroup (4.19±2.76) mg] were less than those in control group [CC subgroup (9.31±3.58) mg, LE subgroup (7.58±3.83) mg] (P=0.012, P=0.015). Human menopausal gonadotropin (hMG) level was less in study group [LE subgroup (209.4±50.2) IU] than in control group [LE subgroup (293.5±61.4) IU] (P=0.010). Endometrial thickness, the rate of ovulation, ovarian hyperstimulation syndrome (OHSS) occurrence rate, clinical pregnancy rate, multiple pregnancy rate, and spontaneous abortion rate were not significantly different between the two groups. Conclusion Ovulation induction in non-menstrual period in PCOS is a valuable and flexible method due to the similar ovulation and clinical pregnancy rate, less stimulation follicle days, less dosage of estrodiol and hMG compared with the traditional method. Key words: Polycystic ovary syndrome (PCOS); Infertility; Non-menstrual period; Ovulation induction