Selective and sensitive poly- ortho -phenylenediamine-shielded microsensore and biosensors for in vivo neurochemical monitoring
2008
Different methodologies are being developed, such as imaging, spectroscopy and
electrochemistry, to study neurochemical dynamics in cell cultures or in intact brain [1-2]. One of
these techniques involves the in-situ detection of biologically active molecules, including nitric
oxide (NO) [3], glucose [4], glutamate (GLUT) [5-6] and lactate [1,7], in brain extracellular fluid
(ECF), using implanted microsensors and biosensors. NO is a water-soluble free radical that
readily diffuses through membranes and its actions in the CNS are largely studied.
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