Growth Hormone Releasing Hormone in Endothelial Barrier Function.

Growth hormone releasing hormone (GHRH) is the integral regulator of the growth hormone (GH)–insulin-like growth factor 1 (IGF-1) axis. It exerts mitogenic effects in a plethora of progressive cancers. Recent evidence suggests the emerging role of that 44-amino acid (aa) neuropeptide in lung endothelial barrier function (EBF), which will be discussed herein.