Clinical Observation on the Curative Effects of Topiramate for Epilepsy

Objective To evaluate the clinical efficiency and the reaction of topiramate (TPM) used long-term for various types of epilepsy and the way to administer the drug. Methods 146 cases with epilepsy were randomly assigned to 2 groups: Group A (n=81) treated with routine antiepileptic combining with topiramate, while Group B treated only with topiramate. The dose of topiramate began with small amount, 6.25mg/d for child under 20 Kg in body weight, 12.5mg/d for child over 20Kg, and 25mg/d for adults. The dose was readapted according the status and untoward reaction respectively. The observation went on 1 year to 3 years and 10 months, average time was 16.2 months. The frequency of epileptic attack 20 weeks and 1 year after treatment was compared with the frequency of basic stage 3 months before treatment. Results The effective rate was 87.8% and 80.2% in group B and group A respectively. The total average effective rate was 83.6% 1 year after treatment. Side effects often were found in the augmented dose period, and the rate in group B was less than that in group A. The difference between the two groups was significant. Conclusions TPM is a kind of new antiepileptic with the features of broad-spectrum, high performance and secure. The various conditions of different patients should be given more attention.