Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells

Objective Pulmonary arterial hypertension, characterized by pulmonary vascular remodeling and vasoconstriction, is associated with excessive proliferative changes in the pulmonary vascular wall. However the role of HDACs in phenotypic alteration of pulmonary arterial smooth muscle cell (PASMC) is largely unknown.