Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA
2017
To the editor:
The central nervous system (CNS) is a key site of extramedullary disease in pediatric acute lymphoblastic leukemia (ALL),[1][1] and prior to the development of contemporary risk-adapted treatment strategies, CNS involvement was inevitable in most cases.[1][1] However, the biology of
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