Arrhythmien als Indikator für eine Reperfusion nach akutem Myokardinfarkt

For the purposes of the European double blind and randomized study 27 patients with acute myocardial infarction underwent thrombolysis with rt-PA (60 mg over 90 minutes i.v.) or placebo. To evaluate whether arrhythmias, especially ventricular arrhythmias indicate coronary reperfusion after thrombolysis a 24 hour Holter monitoring was performed from the beginning of the rt-PA or placebo infusion. Typical reperfusion arrhythmias were thought to be idioventricular rhythms (rate 110/min) or bradycardic rhythm disturbances (rate <50/min). The effect of thrombolysis on reperfusion of the infarct related artery was evaluated 90 minutes after the infusion by coronary angiography.