Evaluation of the Wound Healing Activity of Chenopodium botrys Leaves Essential Oil in Rats (A Short-Term Study)

AbstractChenopodium botrys (CB) is a native plant in Iran which has been used as an anti-inflammatory, antioxidant, antidiabetic, antibacterial, antifungal, antiparasitic, and antiviral agent in traditional medicine of Iran. In this study, the authors describe the effects of essential oil of CB on cutaneous wound healing markers in Sprague-Dawley male rats. The results of GC-MS indicated that the most frequently found chemical constituents in CB essential oil were α-Eudesmol, Epi-α-muurolol, and Cubenol. Full-thickness excisional wounds (2×2 cm) were induced on the back of 24 rats. In this study, rats were randomly divided into four main groups (n=6), including untreated (control), treated with 1 ml basal cream (Placebo), treated with 1 ml tetracycline (3 %), and treated with 1 ml CB essential oil (6 %) for 10 days. The animals of each group were euthanized at 10 days post-injury (DPI), and wounds were evaluated by gross, histometrical and histomorphological analyses. In gross study, the animals treated w...