CNS oxygen toxicity.

This short manuscript will briefly present our current knowledge about CNS oxygen toxicity: the clinical manifestations, descriptions and incidence of symptoms, and the time – duration relationship that defines the safety limits and risk factors leading to enhanced toxicity to hyperbaric oxygen. A very general outline will present suggested mechanisms underlying hyperoxia-induced seizures and strategies for protection against the seizures. Unfortunately, not much has been gained in our knowledge and understanding of CNS oxygen toxicity in recent years. Some concluding remarks will be given, as will some suggestions toward further research for increasing our knowledge about mechanisms, and better approaches for protection against the toxic effects of breathing oxygen at high partial pressures.