Reduction of brain specific gravity in mice prenatally exposed to trichloroethylene

Abstract The specific gravity of the brain is low at birth and increases in parallel with myelination and maturation. The brain specific gravity of litters from mice exposed to trichloroethylene (TCE) before and after mating was significantly lower than in litters from unexposed parents at birth as well as at the age of 10 and 20–22 days. This might indicate a delayed maturation. No significant difference between exposed and unexposed litters was observed at the age of one month.