DYNAMICS OF FIGURES OF VENTILATION FUNCTION OF EXTERNAL RESPIRATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA WITH CONCOMITANT IRRITABLE BOWEL SYNDROME

The aim of the work is to study the ventilation function of external respiration (FER) and the nature of its changes in response to bronchodilator in patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) with concomitant irritable bowel syndrome (IBS). Material and methods. 50 patients with COPD, 50 patients with BA, 50 persons with COPD and IBS and 50 patients with BA and IBS during the exacerbation of the underlying disease were examined. The age of patients ranged from 24 to 65 years: 115 men and 85 women. The main method of diagnosis of bronchial obstruction is the study of the ventilation function of external respiration (FER) using computer spirography with the analysis of the curve "flow-volume", which was carried out on a computer spirography Eger. To determine the reversibility of obstruction, samples with inhaled bronchodilator salbutamol were used. Results . In patients with COPD, there was a decrease in both FEV 1 and FVC. The degree of spirometric disorders correlated with the severity of the disease. The obstructive type of graphic image of the curve "flow-volume", which was characterized by a decrease in the volume velocity of the airflow, was observed in all patients. The ratios of FEV 1 /FVC % and MEF 25%-75% in all patients with COPD were reduced. The presence of concomitant IBS in patients with moderate BA does not make it possible to achieve complete control over the course of BA, due to the continuance of spasm of the peripheral bronchi, which requires medical correction in the form of increased inhalation therapy of BA. The best single reaction to bronchodilators (increase in FEV 1 on average 19.5±2.3%) was observed in patients with BA with transient generalized obstruction syndrome, with bronchospasm predominance. In patients with BA and IBS with transient generalized obstruction syndrome, the increase in FEV 1 after inhalation of bronchodilator was on average 12.6%±1.7%. Conclusions. Based on the analysis of violations of ventilation FER in patients with COPD with IBS, the predominance of the peripheral type of bronchial variant of persistent generalized bronchial obstruction was revealed. Transient generalized obstruction syndrome with completely reverse obstruction prevailed in patients with BA and IBS, in patients with BA without IBS and continuance of peripheral bronchial spasm in patients with BA with IBS.