New Approach to the Practical Synthesis of Tri- or Tetrasubstituted Pyrimidine Derivatives: A Four-Component Coupling Reaction from a Functionalized Silane, Two Types of Aromatic Nitriles, and Acetals.

A new approach to the synthesis of tri- or tetrasubstituted pyrimidines by a four-component coupling reaction using a functionalized silane, two types of aromatic nitriles, and an acetal is described. The efficient transformation of the pyrimidine framework consisting of an isoxazolyl ring and an ethoxy group to the 1,3,8-triazanaphthalene skeleton also proceeded in nearly quantitative yield.