Effect of temperature on the kinetics of the oxytetracycline biosynthesis process

: Short-term experiments on the effect of temperature on the rate of oxytetracycline biosynthesis and consumption of carbohydrates, ammonium nitrogen and inorganic phosphorus were performed under various conditions of mass exchange. Complete fermentation cycles were also carried out at the same temperatures. It was shown that the temperature optimal under conditions of a short-term experiment was not optimal for the complete fermentation cycle. In the latter case the results also depended on the aeration and agitation conditions. It is suggested that temperature has a nonspecific effect by changing the conditions of oxygen supply to the microbial culture.