Empirical studies about inhibiting proliferation of zedoary turmeric oil, Cinobufacini and Solanine on gastric carcinoma cells

Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P 0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.