Effect of Rosuvastatin on Myocardial Inflammation and Left Ventricular Disfunction After Coronary Microembolization in Rats

Aim To evaluate the effect of rosuvastatin on myocardial inflammation and left ventricular disfunction after coronary microembolization(CME). Methods 48 male SD rats were randomized into control group,CME group,low-dose rosuvastatin group[0.5 mg/(kg·d)] and high-dose rosuvastatin group [3.0 mg/(kg·d)] averagely.Rosuvastatin was fed from pre-to post-CME for two weeks.Αt 3 days post-CME,the expression of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-10(IL-10) in myocardium was assayed by ELISΑ,immunostaining and pathological changes were detected by HE staining.Αt 28 day post-CME,collagen deposition was detected by Masson staining and cardiac function was assessed by echocardiography. Results The levels of TNF-αand IL-1β were lower,and IL-10 was higher in high-dose rosuvastatin group compared with CME group.High-dose but not low-dose rosuvastatin also reduced inflammatory cell infiltration and collagen deposition in farct zone,decreased LVEDD,LVESD and increased LVEF,LVFS. Conclusion In rats with CME,perioperative therapy with high-dose rosuvastatin prevents cardiac remodeling and dysfunction.This benefit may be partly derived from reducing myocardial inflammation.