Abstract 12255: Differential Expression of miRNAs in BAG3-mutation Carriers With Dilated Cardiomyopathy

Introduction: A new familial dilated cardiomyopathy (DCM) was found related to mutations in the antiapoptotic BAG3 gene. MicroRNAs (miRNAs) are short non-coding RNAs playing significant roles in cardiac disease, including DCM, representing new targets of treatment. Hypothesis: No previous studies have evaluated the clinical association between BAG3-related DCM and circulating miRNAs. We aimed to study whether a clinical association between BAG3-related DCM and circulating miRNAs may represent a new tool for the diagnosis and progression assessment of the disease. Methods: Detailed clinical and echocardiographic information was obtained from 21 patients with familial DCM carrying a BAG3 mutation and 20 age-matched healthy subjects, analyzing 1759 circulating miRNAs in symptomatic and asymptomatic BAG3 mutation carriers, and compared to healthy age-matched subjects. Results: The expression profiles showed significant differences between controls and BAG3 mutation carriers for miRNAs 3191-3p, 6769b-3p, 1249-...