Note Synthesis and evaluation of some novel (1,2,4)triazolo(1,5-) pyrimidine derivatives for anticancer activity

Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasion and metastasis. These three malignant properties of cancers differentiate them from benign tumors, which are selflimited, and do not invade. Cancers are caused by abnormalities in the genetic material of the transformed cells these abnormalities may be due to the effects of carcinogens such as tobacco smoke, radiation, chemicals or infectious agents. Other cancer-promoting genetic abnormalities may randomly occur through errors in DNA replication, or are inherited and thus present in all cells from birth. The heritability of cancers is usually affected by complex interactions between carcinogens and the host's genome. Compounds having pyrimidine and triazole nucleus posses pharmacological activities. A wide spectrum of biological activities like anti-inflammatory 1 , antibacterial 2 , antfungal 3 , anti-tubercular 4 are found to be associated with pyrimidine nucleus [1,2,4] triazole posses anti-tubercular, anti-inflammatory, antibacterial, antfungal 5 activities. The required starting compound 1-(4-chlorophenyl)-3-(4-benzyl-2yl) propene-1-one was prepared by known method. Compound I on treatment with guanidine hydrochloride yielded 2-aryl-4-(4-chlorophenyl) pyrimidin2-amine, (II) followed by reaction with benzaldehyde gave aryl-4-(4-chlorophenyl)-N-[(1Z)-phenylmethylene] pyrimidin-2-amine (III). The compound III was condensed with hydrazine hydrate to give 7-(4chlorophenyl)-2-phenyl-1,7-dihydro [1,2,4] triazolo [1,5-α] pyrimidine (4a-l) (Scheme I).