Comparative effects of various T cell subtypes on GVHD in a murine model for MHC-matched unrelated donor transplant.

We decided to re-examine and extend some of our earlier GVHD studies with monoclonal antibody depletion in an H-2 identical, but minor-histocompatibility disparate, mouse model 7−10 to see if any correlations existed between the incidence of GVHD and the presence of immature (CD-4) and 8 negative) T cells in the donor inoculum