Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice

Leandro Marcondes-Alves,Victor Fattori,Sergio M. Borghi,Yuri Lourenco-Gonzalez,Allan J. C. Bussmann,Elisa Yoko Hirooka,Rubia Casagrande,Waldiceu A. Verri,Nilton S. Arakawa

Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice

2019

Leandro Marcondes-Alves
Victor Fattori
Sergio M. Borghi
Yuri Lourenco-Gonzalez
Allan J. C. Bussmann
Elisa Yoko Hirooka
Rubia Casagrande
Waldiceu A. Verri
Nilton S. Arakawa

AbstractAcetaminophen (paracetamol) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses. However, acetaminophen overdose can be fatal. Currently, the only treatment av...

Keywords:

Biochemistry
Acetaminophen
Cytokine
Kaurenoic acid
Chemistry
Oxidative stress
Sphagneticola
Cysteine
Analgesic
Antioxidant
Pharmacology
acetaminophen overdose

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