Circulating EZH2-positive T cells are decreased in multiple sclerosis patients

Sunny Malhotra,Luisa M. Villar,Carme Costa,Luciana Midaglia,Marta Cubedo,Silvia Medina,Nicolás Fissolo,Jordi Río,Joaquín Castilló,José C. Álvarez-Cermeño,Alex Sánchez,Xavier Montalban,Manuel Comabella

Circulating EZH2-positive T cells are decreased in multiple sclerosis patients

2018

Sunny Malhotra
Luisa M. Villar
Carme Costa
Luciana Midaglia
Marta Cubedo
Silvia Medina
Nicolás Fissolo
Jordi Río
Joaquín Castilló
José C. Álvarez-Cermeño
Alex Sánchez
Xavier Montalban
Manuel Comabella

Background Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), suggest an involvement of the histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) in important processes such as cell adhesion and migration.

Keywords:

Immunology
Cell adhesion molecule
Cell adhesion
Biology
Experimental autoimmune encephalomyelitis
EZH2
Multiple sclerosis
Cancer research
Protein subunit
Enhancer
Histone methyltransferase
Immunophenotyping
Peripheral blood mononuclear cell
CD8
Molecular biology
T cell

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