Toxicopathological effects of siddha drug thamira kattu chendooram in Wistar rats

A 28-day repeated dose toxicity study was conducted to evaluate the toxicity of thamira kattu chendooram (TKC) in Wistar rats. Thirty two male rats were randomly distributed eight each into four groups of control, low, mid and high dose. Rats were treated with different doses of TKC for 28 days. Reduced body weight and feed consumption were noticed in the mid and high dose groups. Blood samples were collected for haemato-biochemical analysis at the end of the study. Haematological parameters revealed decreased total erythrocyte count, haemoglobin and packed cell volume in high dose group. Alterations of serum biochemical values were noticed in glucose, total protein, albumin and magnesium. Gross and histopathological examinations did not reveal any treatment related changes.