Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350

Joan Fortuny,Alicia W. Gilsenan,Miguel Cainzos-Achirica,Oscar F. Cantero,Robert W. V. Flynn,Luis A. García Rodríguez,Bianca Kollhorst,Pär Karlsson,Love Linnér,Thomas M. MacDonald,Estel Plana,Ana Ruigómez,Tania Schink,Ryan Ziemiecki,Elizabeth Andrews

Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350

2019

Joan Fortuny
Alicia W. Gilsenan
Miguel Cainzos-Achirica
Oscar F. Cantero
Robert W. V. Flynn
Luis A. García Rodríguez
Bianca Kollhorst
Pär Karlsson
Love Linnér
Thomas M. MacDonald
Estel Plana
Ana Ruigómez
Tania Schink
Ryan Ziemiecki
Elizabeth Andrews

Introduction Given prior safety experience with other 5-HT4 agonists for chronic constipation, an observational, population-based cohort study in five data sources from Germany, Sweden, and the UK was conducted to evaluate the cardiovascular safety of prucalopride.

Keywords:

Diabetes mellitus
Polyethylene glycol
Cohort
Prucalopride
Pharmacology
Medicine
Comparability
Internal medicine
Diagnosis code
Population
Propensity score matching
Observational study
Research design
Cohort study

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