Protective Effects of Aloe Vera on Superovulated Oocytes and Folliculogenesis in Diabetic Mice

Background: Reproductive problems such as impaired folliculogenesis and anovulation are observed in diabetic women. Material and Methods: Objectives: In this study the protective effects of Aloe vera (a traditional herb) on oocytes and ovarian folliculogenesis, were investigated. Methods: For this purpose 25 mice were divided in five groups: control, Aloevera trated mice, insulin treated and aloe vera treated diabetics and diabetics. Diabetes were induced by a single injection of stereptozotocin (190 mg/kg, intraperitoneally). Ovulation and maturation rate, oocytes quality and ovarian folliculogenesis were studied after super ovulation. Results and Conclusions: The results suggest that Aloevera has protective effects on the ovary and oocyte in STZ induced diabetic mice