Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography

Abstract The cochlea is a complex biological machine that transduces sound-induced mechanical vibrations to neural signals. Hair cells within the sensory tissue of the cochlea transduce vibrations into electrical signals, and exert electromechanical feedback that enhances the passive frequency separation provided by the cochlea's traveling wave mechanics; this enhancement is termed cochlear amplification. The vibration of the sensory tissue has been studied with many techniques, and the current state of the art is optical coherence tomography (OCT). The OCT technique allows for motion of intra-organ structures to be measured in vivo at many layers within the sensory tissue, at several angles and in previously under-explored species. OCT-based observations are already impacting our understanding of hair cell excitation and cochlear amplification.