Significant regression of the tumor combined with the high level of plasma cortisol by low-dose administration of O, p'-DDD in a case with Cushing's syndrome caused by adrenocortical carcinoma.

OTOKIDA, K., NAKAMURA, M., TAKEDA, M., ITO, T., KATO, M., MASUDA, T. and TASHIRO, A. Significant Regression of the Tumor Combined with the High Level of Plasma Cortisol by Low-Dose Administration of O, p'-DDD in a Case with Cushing's Syndrome Caused by Adrenocortical Carcinoma. Tohoku J. exp. Med., 1986, 150 (4), 407-411-The effect of o, p'-DDD on a functioning adrenocortical carcinoma is described. A 52-year-old woman, who had a huge adrenocortical carcinoma and pulmonary metastasis, was treated by a low-dose administration of o, p'-DDD, which reduced the tumor size. The excretion of urinary 17-OHCS was decreased, whereas plasma cortisol was not decreased but rather increased. This was considered to be caused that o, p'-DDD functioned as a cytotoxic factor which did not improve the states of hyperkalemia, hyperglycemia and hypertension. This suggested that monitoring to measure multiple steroids in addition to plasma cortisol and urinary 17-OHCS was useful for recognizing the general conditions of patients with adrenocortical carcinoma receiving o, p'-DDD therapy.