Triterpenoids fromSchisandra henryi with cytotoxic effect on leukemia and hela cellsin vitro

Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) were isolated from the stems ofSchisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds1,2 and4 showed moderate cytotoxic activity against Leukemia cellsin vitro. Cytotoxic activity of compounds1–4 showed IC50 of 0.0097, 0.01, 0.097 and 0.0099 ¼mol/mL respectively toward Leukemia cells and IC50 of 0.097, 0.1, 0.097 and 0.099 ¼mol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and ZHela cells