The concentration of the amniotic fluid angiogenin and interleukin-6 in the pregnancy with elevated maternal serum human chorionic gonadotropin during the second trimester

Objective : This study is to measure the level of concentration of angiogenin, a cause of potent neovascularization and a marker of ischemia, and of interleukin-6 (IL-6), an indicator of acute inflammation, in the amniotic fluid of patients with elevated maternal serum free -hCG level during the second-trimester. Materials and Methods : Twenty patients with elevated maternal serum free -hCG level (>2.5 MoM) at double screening test of Down syndrome were compared with the controlled group (-hCG suggests an inadequate angiogenesis. Elevated maternal serum free -hCG levels correlate with fetal growth restriction. IL-6 values in both groups have no significant difference.