Loss of Stability of the Blood Liquid State and Assessment of Shear-Induced Thrombosis Risk

The loss of stability of the blood liquid state causes changes in the blood aggregation, resulting in thrombus formation. Intravascular thrombus formation is intensely studied within modern biophysics by the methods of mathematical simulation. Determining the conditions of shear-induced platelet activation has opened an opportunity for the estimation of thrombus formation risks in particular clinical settings. In this paper, a new approach is proposed to determine the risks of shear-induced thrombus formation. This approach is applicable for a wide range of objects including aorta and mechanical circulatory assist devices. The geometry of the vascular walls in numerical experiments is chosen to be isomorphic to that of the blood vessels in a human body. Promising ways to reduce the risks of thrombus formation activation in high blood flows have been found. The developed technique can be used by physicians to plan personalized strategies for antithrombotic therapy based on individual shear-induced platelet activation risks.