Low-grade gliomas in older patients.

2093 Background: Low grade gliomas account for 10-20% of all primary brain tumors. The outcomes of older patients with low-grade glioma (LGG) are not well known. Methods: After obtaining IRB approval, the Cleveland Clinic Brain Tumor and Neuro-Oncology Center’s database was used to identify older patients defined as those >55 years of age with histologically confirmed grade 2 glioma at the time of diagnosis. Multivariable analysis was conducted with use of a Cox proportional hazards model and a stepwise selection algorithm that used p<.10 as the criteria for entry and p<0.05 as retention in the model to identify independent predictors of survival. Results: Chart records of 61 patients diagnosed between 1991 and 2010 were included for final analysis. In contrast to patients ≤55 years, older patients are more likely to be male (p=.06), have poorer performance status at presentation (p<.0001), more comorbid conditions (p<.0001), present with more neurologic symptoms (p<.0001), have a prior history of cancer ...