Abstract C25: Synthesis of N-substituted [benzoylamino]-5-ethyl-1,2,3,6-tetrahydropyridines as potential anticancer agents

Prostate cancer (PC) is a cancer that forms in the tissues of the prostate which is a gland in the male reproductive system found below the bladder and in front of the rectum. PC is the second leading cause of cancer death in American men. African American men have a greater risk of developing PC and this cancer is more aggressive in this population. Cyclooxygenase-2 (COX-2) is an enzyme that has been found to be up-regulated in inflammation as well as some cancers including breast and some prostate cancers. Tetrahydropyridines (THPs) developed by our research group have been shown to be effective in inhibiting inflammation, the enzyme COX-2 and the growth of some breast cancer cells. Here we have synthesized a series of novel THP derivatives as potential prostate cancer agents. The novel N-[substituted benzoylamino]-5-ethyl-1,2,3,6-tetrahydropyridines were synthesized via sodium borohydride reduction of the corresponding N-[substituted phenylcarbonylimino]-3-ethyl pyridinium ylides. This project was supported by the National Center for Research Resources and the National Institute of Minority Health and Health Disparities of the National Institutes of Health through Grant Number 8 G12 MD007582-28 and 2 G12 RR003020. Citation Format: Elizabeth Henderson, Tiffany Ardley. Synthesis of N-substituted [benzoylamino]-5-ethyl-1,2,3,6-tetrahydropyridines as potential anticancer agents. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C25. doi:10.1158/1538-7755.DISP13-C25