1，4-二氫吡啶衍生物與CT DNA相互作用的電化學研究

The electrochemical behavior of the 1,4-Dihydropyridine Derivatives(1,4-DHP) on the GC electrode was studied by cyclic voltammetry in the absence and presence of calf thymus DNA (CT DNA). The results show that the potential of the oxidation peak of 1,4-DHP (E(subscript Pa)) becomes more positive, and the oxidation process is more difficult with an increase in the electron-attractive ability of the substituent at the C-4 position. The oxidation peak current of 1,4-DHP is decreased and the peak position is shifted to the positive direction when bound with CT DNA, while the degree of these phenomena is decreased with the increase of the steric hindrance of the substituent at the C-4 position.