From Guidelines to Real World: results from the National Multiple Myeloma Registry in Uruguay on 222 newly diagnosed Multiple Myeloma patients from 2012-2015

AbstractIntro: In the last decade, substantial improvements in the understanding of the biology of multiple myeloma and the development of novel therapeutic options have led to increased response rates, progression free survival and overall survival. In underdeveloped countries, it is a huge challenge to adapt for this evolution, both in diagnostic and therapeutic aspects.Methods: We conducted a retrospective, national analysis of all patients with newly diagnosed multiple myeloma in a recent period. Diagnostic and prognostic evaluation are carried out according to international recommendations in the majority of patients.Results: The clinical presentation at diagnosis is similar to those reported internationally, although with higher rates of anemia and severe renal failure. Most patients were diagnosed in advanced Durie-Salmon stage (80%), with high ISS score (48% ISS 3). Treatment, both in candidates and non-candidates to transplantation, is conditioned by a limited supply of possibilities, scarce avai...