The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function
2017
Regulatory T (Treg) cells are a subset of immune cells that maintain homeostasis by promoting immune tolerance
and suppressing the immune response via a variety of mechanisms such as secreting cytokines, killing reactive
immune cells, and inducing anergy. Dysfunction of Treg cells has been implicated in inflammatory diseases such as
autoimmunity and transplant rejection. Conversely, too many or hyperresponsive Treg cells has been observed in
cancer and chronic infections. Treg cells have proven to be difficult to study as there are no definitive Treg surface
markers. Additionally, Tregs can gain pro-inflammatory phenotype depending on stimuli. In this commentary, we
discuss the expression and function of members of the Ikaros family of transcription factors during Treg cell
development and activation.
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