Structural Modifications of the Potassium Channel Activator Cromakalim: The C-3 Position.
1991
The syntheses of a selection of C-3 analogues of 6-cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol, the potassium channel activator cromakalim 1, are described. Particular interest has focused on the corresponding 3-ketone 2 and compounds in which the hydroxy group of 1 has been replaced by fluorine, carbon and nitrogen containing residues. The hindered neopentylic nature of the C-3 hydroxy group in 1 has a marked effect on its reactivity and has necessitated the independent synthesis of many of these analogues from simpler precursors rather than from the direct modification of compound 1 itself.
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