이산화규소 나노입자의 마우스 복강 내 주입에 의한 급성독성

본 연구는 이산화규소 나노입자의 급성독성을 확인하기 위해 여러 농도로 마우스의 복강에 주사한 다음 24시간 후에, 혈액학적, 혈액생화학적, 그리고 병리조직학적인 검사를 수행하였다. 혈액학적 검사에서, group II (100 mg/kg 이산화규소 나노입자)에서는 lymphocyte와 monocyte의 수치가 대조군과 비교하여 통계적으로 유의한 차이를 나타내었으며(p 【For the application of nano-sized material in various fields, the evaluation of nano-sized material toxicity is important. In the present study, various concentrations of 200 nm-sized silicon dioxide nanoparticle suspension were intraperitonially injected into mice to identify the toxicity of silicon dioxide nanoparticle in vivo. In the hematological analysis of group II treated with silicon dioxide nanoparticle 100 mg/kg body weight, lymphocytes and monocytes were significantly different compared to the control group. In group III treated with silicon dioxide nanoparticle 200 mg/kg body weight, lymphocytes, monocytes and hemoglobin were significantly different compared to the control group. In blood biochemical analysis of group III, the concentration of AST, ALT, BUN, and creatinine were significantly different compared to the control group. Histopathologic examination of the kidney indicated a mild injury only in mice received 200 mg/kg silicon dioxide nanoparticle. According to the results of the present study, the significant differences in the hematological and blood biochemical analyses and abnormal histopathological findings in the mouse kidney may have been related to exposure to silicon dioxide nanoparticle.】