In vitro cisplatin effects on phagocyte functions

The effects of cis-diamminedichloroplatinum (11) (cisplatin), a drug used in cancer chemotherapy, on the oxidative metabolism, endocytosis, chemotaxis and exocytosis of guinea-pig polymorphonuclear leukocytes were studied. All these functions were negatively influenced, but the same effect (50% inhibition) was observed at different drug concentrations (3 × 10−5 M for chemotaxis, 10−4 M for O2 consumption by FMLP and β-glucuronidase release, 10−3 M for O2 consumption by PMA and for zymosan engulfment). The effects of the drug can be explained by its ability to bind to membrane proteins, essentially to -SH groups.