Synthesis of CF3-Containing Isoindolinone Derivatives through Rhodium-Catalyzed Oxidative Coupling of Benzamides with 2-Trifluoromethylacrylate

The oxidative coupling of benzamides with methyl 2-trifluoromethylacrylate proceeds smoothly under rhodium(III) catalysis to produce trifluoromethyl-substituted isoindolinone derivatives. The catal...