Compositions and methods for inhibiting RNA-si angiongenesis.

A ribonucleic acid isolated short interfering (siRNA) comprising a sense RNA strand from about 19 to about 25 nucleotides in length and a string of anti-sense RNA of about 19 to about 25 nucleotides in length, wherein the chains sense RNA and anti-sense form an RNA duplex, and wherein the sense RNA strand comprises a nucleotide sequence identical to the target sequence in mRNA factor human vascular endothelial growth factor (VEGF) wherein said target sequence is selected from SEQ ID NO: 47 , SEQ ID NO: 48, SEQ ID NO: 50, SEQ ID NO: 51, SEQ ID NO: 52 and SEQ ID NO: 56.