Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yoshikazu Yokono,Kenji Hanada,Masato Narita,Yota Tatara,Yousuke Kawamura,Naotake Miura,Kazutaka Kitayama,Masamichi Nakata,Masashi Nozaka,Tomo Kato,Natsumi Kudo,Michiko Tsushima,Yuichi Toyama,Ken Itoh,Hirofumi Tomita

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

2020

Yoshikazu Yokono
Kenji Hanada
Masato Narita
Yota Tatara
Yousuke Kawamura
Naotake Miura
Kazutaka Kitayama
Masamichi Nakata
Masashi Nozaka
Tomo Kato
Natsumi Kudo
Michiko Tsushima
Yuichi Toyama
Ken Itoh
Hirofumi Tomita

Background Although PAR‐1 (protease‐activated receptor‐1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR‐1 signaling in heart failure development re...

Keywords:

Protease-activated receptor
Blockade
Endocrinology
Cardiology
Internal medicine
Renin–angiotensin system
Cardiac fibrosis
Fibrosis
Diabetes mellitus
cardiac hypertrophy
Medicine
Pathophysiology
Heart failure

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