Assessing the impact of biosimulation on target selection and validation
2003
Abstract Predictive biosimulation provides the unique ability to explore, in a human in vivo context, the potential impact of novel or known targets on clinical outcome. This approach also allows the identification and exploration of knowledge gaps, leading to a better understanding of disease pathophysiology, and can focus laboratory experimentation on the crucial pathways involved in the disease, making the process of target validation more efficient.
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