Medium molecular size peptides of blood plasma in diabetes mellitus

: The level of medium molecular peptides (MMP) grows up in blood plasma of patients with diabetes mellitus (DM), which results in endogenous intoxication. The MMP concentration is high in patients with insulin-independent DM at compensation and without renal affection versus insulin-dependent DM, which is explained by presence of 1-3 kDa peptides. An aggravated course of DM including subcompensation is associated with a higher MMP level in patients with both DM types. The onset of the initial stage of diabetic nephropathy brings about an essential decrease of all MMP fractions in both DM types.