Thiosulfonylation of alkenes with the insertion of sulfur dioxide under non-metallic conditions
2018
A three-component reaction of 1-(2-allylaryl)thioureas, sulfur dioxide, and aryldiazonium tetrafluoroborates under mild conditions is realized, leading to sulfonated [3,1]-benzothiazepines in good yields. The reaction proceeds smoothly at room temperature in the absence of any catalysts or additives. A high efficiency is observed for this non-metallic transformation. Preliminary mechanistic investigation shows that a radical process is involved. This protocol represents an efficient and attractive strategy for the preparation of seven-membered heterocyclic compounds containing a sulfonyl group.
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