Histological subtype analysis of colon cancer: A population-based study—Different sides and different diseases.

e14655 Background: Retrospective analyses and case series showed an unfavourable outcome of mucinous colon cancer and a poorer response to treatment compared with non-mucinous tumours. Contradictory reports suggest that the clinical relevance of this histological type remains unclear. Methods: The authors evaluated incidence, survival and genetic alteration of colon adenocarcinomas in the incident colon cancer population systematically collected by the Parma Province Cancer Registry between 2004 and 2007. An adenocarcinoma was defined as mucinous if > 50% of the lesion was composed of extracellular mucin. Histopathological slides were reviewed for the present analysis. Results: 1077 patients with a diagnosis of stage I to IV colon cancer were analyzed for study purposes: 107 mucinous (10%) and 970 (90%) non-mucinous tumours. A higher proportion of mucinous carcinomas compared with non-mucinous tumours were diagnosed at advanced stage (stage III 38% and stage I 10% vs 29% and 24%, respectively; p = 0.01), ...