It is a kind of can the sustained release growth factor Bone Defect Repari adhesive and preparation method thereof

The invention belongs to technical field of biological materials, be related to it is a kind of can the sustained release growth factor Bone Defect Repari adhesive and preparation method thereof.The present invention, which is reacted by heparin modified cyanoacetic acid and further with formaldehyde, prepares the test tube of hepari cyanoacrylamide monomer with that can load and be sustained growth factor, then test tube of hepari cyanoacrylamide monomer pre-polymerization under methanol effect is merged into the load of row growth factor, finally growth factor-loaded prepolymerization product and test tube of hepari cyanoacrylamide monomer are mixed, obtain can the sustained release growth factor Bone Defect Repari adhesive.It is provided by the invention can the sustained release growth factor Bone Defect Repari adhesive have the function of load and slow release growth factor, with quick-binding and bone tissue reparation can be promoted in the application processes such as bone and cartilage bonding, bone tissue reparation；Meanwhile also having the characteristics that strong cohesive force, stable chemical performance and good biocompatibility.